Filizola Lab Members

Jennifer Johnston, Ph.D.

Postdoctoral Associate

Mailing Address:

Dept. of Structural and Chemical Biology
Mount Sinai School of Medicine
Icahn Medical Institute Building
1425 Madison Avenue, Box 1677
New York, NY 10029-6574
Tel.:212-659-5406
Fax: 212-849-2456
Email:Jennifer.Johnston@mssm.edu

Research Interest:

I am currently working on the oligomerization of opioid receptors, using coarse grained metadynamics, homology modeling, and other techniques, in order to predict dimerization disruption. Previously, I have worked on coarse grained models of the human stratum
corneum, and performed potential of mean force calculations to predict the permeation characteristics of small molecules through this model membrane.

Training and Education

- Postdoctoral Associate, Dept. of Structural and Chemical Biology, Mt Sinai School of Medicine, New York. 2009 - present.
- Postdoctoral Fellow, Dept. of Physiology, Johns Hopkins Medical Institutes, Baltimore, MD. 2006-2008. Working under the supervision of Professor Thomas B. Woolf.
- DPhil Student, Dept. of Biochemistry, University of Oxford, UK. 2002-2006. Under the supervision of Professor Mark SP Sansom. Thesis: "Computational studies of alpha helical membrane proteins."
- MNatSc (Chemistry), University of Birmingham, UK. 1998-2002.

Publications

1- Johnston JM, Khalid S, Sansom MS. "Conformational dynamics of the mitochondrial ADP/ATP carrier: a simulation study". Mol Membr Biol. 2008 Sep;25(6-7):506-17.

2- Jang H, Michaud-Agrawal N, Johnston JM, Woolf TB. "How to lose a kink and gain a helix: pH independent conformational changes of the fusion domains from influenza hemagglutinin in heterogeneous lipid bilayers". Proteins. 2008 Jul;72(1):299-312.

3- Johnston JM, Cook GA, Tomich JM, Sansom MS. "Conformation and environment of channel-forming peptides: a simulation study". Biophys J. 2006 Mar 15;90(6):1855-64.

4- Habershon, S; Harris, KDM; Johnston, RL; Turner, GW and Johnston, JM. "Gaining insights into the evolutionary behaviour in genetic algorithm calculations, with applications in structure solution from powder diffraction data". Chem Phys Lett 2002 Feb 19;353(3-4):185-194.