Aggarwal Group Publications


 

Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. 
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. 
Nature. 2003 Nov 20;426(6964):247-54.

Vanamee ES, Hsieh P, Zhu Z, Yates D, Garman E, Xu S, Aggarwal AK. 
Glucocorticoid receptor-like Zn(Cys)4 motifs in BslI restriction endonuclease.
J Mol Biol. 2003 Nov 28;334(3):595-603. 
  
Edwards TA, Wilkinson BD, Wharton RP, Aggarwal AK.  
Model of the brain tumor-Pumilio translation repressor complex.
Genes Dev. 2003 Oct 15;17(20):2508-13. 

James JA, Escalante CR, Yoon-Robarts M, Edwards TA, Linden RM, Aggarwal AK. 
Crystal structure of the SF3 helicase from adeno-associated virus type 2.  
Structure (Camb). 2003 Aug;11(8):1025-35. 

Viadiu H, Vanamee ES, Jacobson EM, Schildkraut I, Aggarwal AK. 
Crystallization of restriction endonuclease SfiI in complex with DNA.
Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1493-5. 

Green JB, Gardner CD, Wharton RP, Aggarwal AK.  
RNA recognition via the SAM domain of Smaug.
Mol Cell. 2003 Jun;11(6):1537-48. 

Sun J, Viadiu H, Aggarwal AK, Weinstein H.
Energetic and Structural Considerations for the Mechanism of Protein Sliding along DNA in
 the Nonspecific BamHI-DNA Complex.
Biophys J 2003 May;84(5):3317-25

Johnson RE, Trincao J, Aggarwal AK, Prakash S, Prakash L.
Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases.
Mol Cell Biol 2003 Apr;23(8):3008-12

Aggarwal AK, Doudna JA.Protein-nucleic acid interactions.
Curr Opin Struct Biol 2003 Feb;13(1):3-5

Escalante CR, Brass AL, Pongubala JM, Shatova E, Shen L, Singh H, Aggarwal AK.
Crystal structure of PU.1/IRF-4/DNA ternary complex.
Mol Cell 2002 Nov;10(5):1097-105

Kumar V, Carlson JE, Ohgi KA, Edwards TA, Rose DW, Escalante CR, Rosenfeld MG, Aggarwal AK.
Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase.
Mol Cell 2002 Oct;10(4):857-69

Dean KA, Aggarwal AK, Wharton RP.
Translational repressors in Drosophila.
Trends Genet 2002 Nov;18(11):572-7

Green JB, Edwards TA, Trincao J, Escalante CR, Wharton RP, Aggarwal AK.
Crystallization and characterization of Smaug: a novel RNA-binding motif.
Biochem Biophys Res Commun 2002 Oct 11;297(5):1085-8

Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK.
Crystallization and characterization of PU.1/IRF-4/DNA ternary complex.
J Struct Biol 2002 Jul;139(1):55-9

Escalante CR, Shen L, Thanos D, Aggarwal AK.
Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the
 interferon-beta promoter..
Structure (Camb) 2002 Mar;10(3):383-91

Trincao J, Johnson RE, Escalante CR, Prakash S, Prakash L, Aggarwal AK. 
Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis. 
Mol Cell. 2001 Aug;8(2):417-26.

Vanamee ES, Santagata S, Aggarwal AK. 
FokI requires two specific DNA sites for cleavage. 
J Mol Biol. 2001 May 25;309(1):69-78.

Edwards TA, Pyle SE, Wharton RP, Aggarwal AK. 
Structure of Pumilio reveals similarity between RNA and peptide binding motifs. 
Cell. 2001 Apr 20;105(2):281-9.

Edwards TA, Trincao J, Escalante CR, Wharton RP, Aggarwal AK. 
Crystallization and characterization of Pumilo: a novel RNA binding protein. 
J Struct Biol. 2000 Dec;132(3):251-4.

Yoon M, Smith DH, Ward P, Medrano FJ, Aggarwal AK, Linden RM. 
Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro. 
J Virol. 2001 Apr;75(7):3230-9.

Lukacs CM, Aggarwal AK. 
BglII and MunI: what a difference a base makes. 
Curr Opin Struct Biol. 2001 Feb;11(1):14-8. 

Lukacs CM, Kucera R, Schildkraut I, Aggarwal AK. 
Structure of free BglII reveals an unprecedented scissor-like motion for opening an endonuclease. 
Nat Struct Biol. 2001 Feb;8(2):126-30.

Senger K, Merika M, Agalioti T, Yie J, Escalante CR, Chen G, Aggarwal AK, Thanos D. 
Gene repression by coactivator repulsion. 
Mol Cell. 2000 Oct;6(4):931-7.

Scully KM, Jacobson EM, Jepsen K, Lunyak V, Viadiu H, Carriere C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG.
Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. 
Science. 2000 Nov 10;290(5494):1127-31.

Viadiu H, Aggarwal AK. 
Structure of BamHI bound to nonspecific DNA: a model for DNA sliding. 
Mol Cell. 2000 May;5(5):889-95.

Qiu L, Escalante CR, Aggarwal AK, Wilson PD, Burrow CR. 
Monomeric midkine induces tumor cell proliferation in the absence of cell-surface proteoglycan binding. 
Biochemistry. 2000 May 23;39(20):5977-87.

Viadiu H, Kucera R, Schildkraut I, Aggarwal AK. 
Crystallization of restriction endonuclease BamHI with nonspecific DNA.
J Struct Biol. 2000 May;130(1):81-5.

Lukacs CM, Kucera R, Schildkraut I, Aggarwal AK. 
Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 A resolution. 
Nat Struct Biol. 2000 Feb;7(2):134-40.

Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM. 
1H, 15N and 13C resonance assignments for the bromodomain of the histone acetyltransferase P/CAF. 
J Biomol NMR. 1999 Jul;14(3):291-2. 

Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG. 
Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. 
Cell. 1999 May 28;97(5):587-98.

Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM.
Structure and ligand of a histone acetyltransferase bromodomain. 
Nature. 1999 Jun 3;399(6735):491-6.

Passner JM, Ryoo HD, Shen L, Mann RS, Aggarwal AK. 
Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. 
Nature. 1999 Feb 25;397(6721):714-9.

Viadiu H, Aggarwal AK. 
The role of metals in catalysis by the restriction endonuclease BamHI. 
Nat Struct Biol. 1998 Oct;5(10):910-6.

Xu L, Lavinsky RM, Dasen JS, Flynn SE, McInerney EM, Mullen TM, Heinzel T, Szeto D, Korzus E, Kurokawa R, Aggarwal AK, Rose DW, Glass CK, Rosenfeld MG. 
Signal-specific co-activator domain requirements for Pit-1 activation. 
Nature. 1998 Sep 17;395(6699):301-6.

Bitinaite J, Wah DA, Aggarwal AK, Schildkraut I. 
FokI dimerization is required for DNA cleavage. 
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10570-5.

Wah DA, Bitinaite J, Schildkraut I, Aggarwal AK. 
Structure of FokI has implications for DNA cleavage. 
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10564-9.

Aggarwal AK, Wah DA. 
Novel site-specific DNA endonucleases. 
Curr Opin Struct Biol. 1998 Feb;8(1):19-25. Review.

Escalante CR, Yie J, Thanos D, Aggarwal AK. 
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. 
Nature. 1998 Jan 1;391(6662):103-6.

Escalante CR, Yie J, Thanos D, Aggarwal AK. 
Expression, purification, and co-crystallization of IRF-I bound to the interferon-beta element PRDI. 
FEBS Lett. 1997 Sep 8;414(2):219-20.

Wah DA, Hirsch JA, Dorner LF, Schildkraut I, Aggarwal AK. 
Structure of the multimodular endonuclease FokI bound to DNA. 
Nature. 1997 Jul 3;388(6637):97-100.

Aggarwal AK. 
Homing in on intron-encoded endonucleases. 
Nat Struct Biol. 1997 Jun;4(6):423-4. No abstract available.

Hirsch JA, Wah DA, Dorner LF, Schildkraut I, Aggarwal AK. 
Crystallization and preliminary X-ray analysis of restriction endonuclease FokI bound to DNA. 
FEBS Lett. 1997 Feb 17;403(2):136-8.

Jacobson EM, Li P, Leon-del-Rio A, Rosenfeld MG, Aggarwal AK. 
Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. 
Genes Dev. 1997 Jan 15;11(2):198-212.