Papers

Chen J., DeVivo M., Dingus J., Harry A., Li J., Sui J., Carty D., Blank J.L., Exton J., Stoffel, R.H., Inglese J., Lefkowitz R.J., Logothetis D.E., Hildebrandt J.D. and Iyengar R.  1995.  A region of adenylyl cyclase 2 critical for regulation by G protein bg subunits.  Science  268:1166-1169. Pubmed

Chan KW, Langan MN, Sui J, Kozak JA, Pabon A, Ladias JAA, and Logothetis DE.  1996.  A recombinant inwardly-rectifying potassium channel coupled to GTP-binding proteins. J. Gen. Physiol. 107:381-397. Pubmed

Sui J-L, Chan KW, and Logothetis DE.  1996.  Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism. J. Gen. Physiol. 108: 381-391. Pubmed

Chan KW, Sui J, Vivaudou M, and Logothetis DE.  1996. Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit.  PNAS 93: 14193-14198. Pubmed

Chan KW, Sui J-L, Vivaudou M, and Logothetis DE.  1997. Specific regions of heteromeric subunits involved in the enhancement of G-protein-gated K+ channel activity. J. Biol. Chem. 272: 6548-6555. Pubmed

Kozak JA and Logothetis DE.  1997.  A calcium-dependent chloride current in insulin-secreting b-TC3 cells. Pflugers Arch. 433: 679-690. Pubmed

Vivaudou M, Chan KW, Sui J-L, Jan LY, Reuveny E., and Logothetis DE. 1997.  Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants. J. Biol. Chem. 272:31553-31560. Pubmed

Sui J-L, Petit-Jacques J, and Logothetis DE. 1998.  Activation of the atrial KACh channel by the bg subunits of G proteins or intracellular Na+ ions depends on the presence of Phosphatidylinositol phosphates. PNAS 95:1307-1312. Pubmed

Kozak JA and Logothetis DE. 1998. Characterization of a Ca2+-activated K+ current in insulin-secreting b-TC3 cells.  J. Physiol. London 509:355-370. Pubmed

He C, Zhang H, Mirshahi T, and Logothetis DE.  1999.  Identification of a potassium channel site that interacts with G protein beta gamma subunits to mediate agonist-induced signaling.  J. Biol. Chem. 1999, 274: 12517-12524. Pubmed

Zhang H, He C, Yan X, Mirshahi T, and Logothetis DE.  1999. Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biology  1:183-188. Pubmed

Sui JL, Chan K, Langan MN, Vivaudou M, Logothetis DE. 1999. G protein gated potassium channels. Adv Second Messenger Phosphoprotein Res. 33:179-201. Pubmed

Petit-Jacques J, Sui J-L, and Logothetis DE.  1999. Synergistic activation of GIRK channels by Na+, Mg2+ and Gbg subunits.  J. Gen. Physiol. 114:673-684. (Cover) Pubmed

Logothetis DE and Zhang H.  Gating of G protein-sensitive inwardly rectifying K+ channels through PIP2.  J. Physiol. London 1999; 520:630. Pubmed

Rohacs T, Chen J, Prestwich GD, and Logothetis DE.  1999. Distinct specificities of inwardly rectifying K+ channels for phosphoinositides. J. Biol. Chem. 274:36065-36072. Pubmed

Kobrinsky E, Mirshahi T, and Logothetis DE.  2000. Agonist-induced regulation of the plasma membrane messenger PIP2 results in potassium current desensitization.  Nature Cell Biology 2:507-514. Pubmed

Pabon A, Chan KW, Sui J-L, Yan X, He C, Logothetis DE, and Thornhill WB.  2000. Glycosylation of GIRK1 at N119 and ROMK1 at N117 have different consequences on potassium channel function. JBC. 275: 30677–30682. Pubmed

Hughes T, Zhang H, Logothetis DE, and Berlot CH.  2001. Visualization of a functional Gaq-green fluorescent protein fusion in living cells:  Association with the plasma membrane is disrupted by mutational activation and by elimination of palmitoylation sites, but not by activation mediated by receptors or AlF4-.  J. Biol. Chem. 276: 4227-4235. Pubmed

Zhu L, Wu X, Chan KW, Logothetis DE, and Thornhill WB.  2001. Cloning and characterization of G protein gated K+ channel (GIRK1) isoforms from heart and brain. Molecular Neuroscience 16:21-32. Pubmed

Mirshahi T, Robillard L, Zhang H, Hebert TE, and Logothetis DE.  2002. Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels. J. Biol. Chem. 277: 7348-7355. Pubmed

He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, and Logothetis DE. 2002. Identification of critical residues in the cytoplasmic N- and C-terminal domains of GIRK channels involved in interactions with the bg subunits of G proteins and generation of basal activity.  J. Biol. Chem. 277: 6088-6096. Pubmed

Rohacs T, Lopes C, Mirshahi T, Jin T, Zhang H, Logothetis DE. 2002. Assaying phosphatidylinositol bisphosphate regulation of potassium channels. Methods Enzymol. 345:71-92. Pubmed

Lopes CMB, Zhang H, Rohacs T, Yang J, and Logothetis DE.  2002. Alterations in Conserved Interactions between PIP2 and Kir Channels Underlie Channelopathies. Neuron 34:933-944. Pubmed

Mirshahi T, Mittal V, Zhang H, Linder ME, and Logothetis DE.  2002. Distinct Sites on G Protein beta gamma Subunits Regulate Different Effector Functions.  J Biol Chem. 277:36345-50. Pubmed

Mirshahi T and Logothetis DE.  GIRK channel trafficking: Different paths for different family members. (Molecular Interventions In Press)

Jin T., Peng L., Mirshahi T., Rohacs T., Chan K.W., Sanchez R. and Logothetis D.E. 2002. The beta-gamma subunit of G proteins gate a K+ channel by pivoted bending of a transmembrane segment.  Mol. Cell 10:469-481.

Rohacs T, Lopes CMB, Ramdya P, Jin T, and Logothetis DE.  Specificity of phosphoinositide action determines lipid regulation of Kir channels.  (Under Review in PNAS).

Chan KW, Zhang H, and Logothetis DE.  The N-terminal transmembrane domain of sulfonylurea receptors Associates with the Kir6 subunits accounting for KATP channel functional and pathologic characteristics. (Submitted)

Zhang H, Craciun LC, Mirshahi T, Rohacs T, Lopes CMB and Logothetis DE.  PIP2 activates KCNQ channels and its hydrolysis underlies receptor-mediated inhibition of M currents. (Submitted)