We seek self-motivated individuals as Postdoctoral Fellows to study structure-function of protein modular domains and enzymes in chromatin-mediated gene transcription or the RNA interference pathway. Our laboratory is surrounded in a dynamic research environment and equipped with state-of-the-art facilities for biochemical research focused on three-dimensional structural analysis of proteins with high-resolution NMR spectroscopy and X-ray crystallography. Our NMR facility has one 600 MHz and one 500 MHz 4-channel Bruker NMR spectrometers. We also have regular access to a cluster of 800 MHz and 900 MHz NMR systems with cryogenic probes at the New York Structural Biology Center (NYSBC).

The selected individuals will conduct structure-based functional analysis of proteins and structure-based small molecule disovery. Requirements include a recent PhD degree in Chemistry or Biochemistry with solid background and demonstrated experience in protein biochemistry, molecular biology, protein NMR spectroscopy or X-ray crystallography. Skills in recombinant protein techniques and computer programming are preferred.

We offer competitive salaries and excellent benefits along with the support and challenges for performing cutting-edge science. Individuals with matching qualifications should send a curriculum vitae, a statement of research interests, and names of three references to:

Ming-Ming Zhou, PhD
Professor and Chairman
Department of Structural & Chemical Biology
Mount Sinai School of Medicine
1425 Madison Avenue, Box 1677
New York, NY 10029-6574
Phone: (212) 659-8652
Fax: (212) 849-2456
E-mail: Ming-Ming.Zhou@mssm.edu

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