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Publications:
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Rachofsky EL, Seibert E, Stivers JT, Osman R, Ross JB. (2001a). Conformation and Dynamics of Abasic Sites in DNA Investigated by Time- Resolved Fluorescence of 2-Aminopurine. Biochemistry 40(4):957-967. Pub Med
Rachofsky EL, Osman R, Ross JB. (2001b). Probing Structure and Dynamics of DNA with 2-Aminopurine: Effects of Local Environment on Fluorescence. Biochemistry 40(4):946-956. Pub Med
Gershengorn MC, Osman R. (2001). Minireview: Insights into G protein-coupled receptor function using molecular models. Endocrinology 142(1):2-10. Pub Med
Ho HH, Ganeshalingam N, Rosenhouse-Dantsker A, Osman R, Gershengorn MC. (2001). Charged Residues at the Intracellular Boundary of Transmembrane Helices 2 and 3 Independently Affect Constitutive Activity of Kaposi's Sarcoma- associated Herpesvirus G Protein-coupled Receptor. J Biol Chem 276(2):1376- 1382. Pub Med
Rosenhouse-Dantsker A, Osman R. (2000). Application of the primary hydration shell approach to locally enhanced sampling simulated annealing: computer simulation of thyrotropin- releasing hormone in water. Biophys J 79(1):66-79. Pub Med
Osman R, Fuxreiter M, Luo N. (2000). Specificity of damage recognition and catalysis of DNA repair. Comput Chem 24(3-4):331-9. Pub Med
Fuxreiter M, Warshel A, Osman R. (1999). Role of active site residues in the glycosylase step of T4 endonuclease V. Computer simulation studies on ionization states. Biochemistry 38(30):9577-89. Pub Med
Luo N, Mehler E, Osman R. (1999). Specificity and catalysis of uracil DNA glycosylase. A molecular dynamics study of reactant and product complexes with DNA. Biochemistry 38(29):9209-20. Pub Med
Colson AO, Perlman JH, Jinsi-Parimoo A, Nussenzveig DR, Osman R, Gershengorn MC. (1998a). A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation. Mol Pharmacol 54(6):968-78. Pub Med
Yamaguchi H, van Aalten DM, Pinak M, Furukawa A, Osman R. (1998). Essential dynamics of DNA containing a cis.syn cyclobutane thymine dimer lesion. Nucleic Acids Res 26(8):1939-46. Pub Med
Colson AO, Perlman JH, Smolyar A, Gershengorn MC, Osman R. (1998b). Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor. Biophys J 74(3):1087-100. Pub Med
Perlman JH, Colson AO, Jain R, Czyzewski B, Cohen LA, Osman R, Gershengorn MC. (1997a). Role of the extracellular loops of the thyrotropin- releasing hormone receptor: evidence for an initial interaction with thyrotropin- releasing hormone. Biochemistry 36(50):15670-6. Pub Med
Perlman JH, Colson AO, Wang W, Bence K, Osman R, Gershengorn MC. (1997b). Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor. J Biol Chem 272(18):11937- 42. Pub Med
Laakkonen LJ, Guarnieri F, Perlman JH, Gershengorn MC, Osman R. (1996a). A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Novel mixed mode Monte Carlo/stochastic dynamics simulations of the complex between TRH and TRH receptor. Biochemistry 35(24):7651-63. Pub Med
Perlman JH, Laakkonen LJ, Guarnieri F, Osman R, Gershengorn MC. (1996). A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Biochemistry 35(24):7643-50. Pub Med
Laakkonen L, Li W, Perlman JH, Guarnieri F, Osman R, Moeller KD, Gershengorn MC. (1996b). Restricted analogues provide evidence of a biologically active conformation of thyrotropin-releasing hormone. Mol Pharmacol 49(6):1092-6. Pub Med
Pinak M, Yamaguchi H, Osman R. (1996). Molecular dynamics (MD) simulation of DNA dodecamer with 5-hydroxy-6- cytosinyl radical. J Radiat Res (Tokyo) 37(1):20-8. Pub Med
Gershengorn MC, Osman R. (1996). Molecular and cellular biology of thyrotropin-releasing hormone receptors. Physiol Rev 76(1):175-91. Pub Med
Perlman JH, Laakkonen L, Osman R, Gershengorn MC. (1995). Distinct roles for arginines in transmembrane helices 6 and 7 of the thyrotropin-releasing hormone receptor. Mol Pharmacol 47(3):480-4. Pub Med
Miaskiewicz K, Miller J, Ornstein R, Osman R. (1995). Molecular dynamics simulations of the effects of ring-saturated thymine lesions on DNA structure. Biopolymers 35(1):113-24. Pub Med
Perlman JH, Laakkonen L, Osman R, Gershengorn MC. (1994a). A model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Evidence for a second direct interaction between transmembrane helix 3 and TRH. J Biol Chem 269(38):23383-6. Pub Med
Miaskiewicz K, Miller J, Osman R. (1994). Energetic basis for structural preferences in 5/6-hydroxy-5,6- dihydropyrimidines: products of ionizing and ultraviolet radiation action on DNA bases. Biochim Biophys Acta 1218(3):283-91. Pub Med
Shafferman A, Ordentlich A, Barak D, Kronman C, Ber R, Bino T, Ariel N, Osman R, Velan B. (1994). Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase. Embo J 13(15):3448- 55. Pub Med
Miller J, Miaskiewicz K, Osman R. (1994). Structure-function studies of DNA damage using ab initio quantum mechanics and molecular dynamics simulation. Ann N Y Acad Sci 726:71-91. Pub Med
Perlman JH, Thaw CN, Laakkonen L, Bowers CY, Osman R, Gershengorn MC. (1994b). Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor. J Biol Chem 269(3):1610- 3. Pub Med
Smolyar A, Osman R. (1993). Role of threonine 342 in helix 7 of the 5- hydroxytryptamine type 1D receptor in ligand binding: an indirect mechanism for receptor selectivity. Mol Pharmacol 44(4):882-5. Pub Med
Miaskiewicz K, Miller J, Osman R. (1993). Ab initio theoretical study of the structures of thymine glycol and dihydrothymine. Int J Radiat Biol 63(6):677-86. Pub Med
Perlman JH, Laakkonen L, Thaw CN, Osman R, Gershengorn MC. (1993). Analysis of the role of transmembrane helix three of the thyrotropin- releasing hormone (TRH) receptor in directly binding TRH. Trans Assoc Am Physicians 106:162-7. Pub Med
Perlman JH, Nussenzveig DR, Osman R, Gershengorn MC. (1992). Thyrotropin- releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors. J Biol Chem 267(34):24413-7. Pub Med
Pardo L, Ballesteros JA, Osman R, Weinstein H. (1992). On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three- dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors. Proc Natl Acad Sci U S A 89(9):4009-12. Pub Med
Ben-Harari RR, Dalton BA, Osman R, Maayani S. (1991). Kinetic characterization of 5-hydroxytryptamine receptor desensitization in isolated guinea-pig trachea and rabbit aorta. J Pharmacol Exp Ther 257(1):416-24. Pub Med
Osman R, Pardo L, Banfelder J, Mazurek AP, Shvartzman L, Strauss R, Weinstein H. (1991a). Molecular mechanisms of radiation induced DNA damage: H-addition to bases, direct ionization and double strand break. Free Radic Res Commun 12-13(Pt 2):465-7. Pub Med
Osman R, Weinstein H. (1991). A mechanistic basis for design of selective agonists for 5-HT receptors. NIDA Res Monogr 112:21-42. Pub Med
Osman R, Miaskiewicz K, Weinstein H. (1991b). Structure-function relations in radiation damaged DNA. Basic Life Sci 58:423-47. Pub Med
Pardo L, Osman R, Banfelder J, Mazurek AP, Weinstein H. (1991). Molecular mechanisms of radiation induced DNA damage: H-abstraction and beta-cleavage. Free Radic Res Commun 12-13(Pt 2):461-3. Pub Med
Keitz SA, Osman R, Clarke WP, Goldfarb J, Maayani S. (1990). Functional interactions in smooth muscle: kinetic characterization of the relaxation and desensitization responses to a beta adrenergic agonist in the rabbit aorta. J Pharmacol Exp Ther 255(2):650-6. Pub Med
Osman R, Keitz SA, Goldfarb J, Maayani S. (1990). Kinetics of response and drug action. Neuropsychopharmacology 3(5-6):417-25. Pub Med
Weinstein H, Osman R. (1990). On the structural and mechanistic basis of function, classification, and ligand design for 5-HT receptors. Neuropsychopharmacology 3(5-6):397-409. Pub Med
Osman R, Clark WJ, Mazurek AP, Weinstein H. (1989b). Theoretical studies of molecular mechanisms of DNA damage induced by hydroxyl radicals. Free Radic Res Commun 6(2-3):131-2. Pub Med
Mercier GA, Osman R, Weinstein H. (1989). A molecular theoretical model of recognition and activation at a 5-HT receptor. Prog Clin Biol Res 289:399-410. Pub Med
Mercier GA, Osman R, Weinstein H. (1988). Role of primary and secondary protein structure in neurotransmitter receptor activation mechanisms. Protein Eng 2(4):261-70. Pub Med
Weinstein H, Osman R, Mercier G. (1988). Recognition and activation of a 5-HT receptor by hallucinogens and indole derivatives. NIDA Res Monogr 90:243-55. Pub Med
Osman R, Topiol S, Rubenstein L, Weinstein H. (1987). A molecular model for activation of a 5-hydroxytryptamine receptor. Mol Pharmacol 32(5):699-705. Pub Med
Clancy BM, Osman R, Maayani S. (1987). Kinetics of competitive drug action at 5-hydroxytryptamine2 receptors in isolated rabbit aorta. J Pharmacol Exp Ther 242(1):108-14. Pub Med
Mazurek AP, Osman R, Weinstein H. (1987). Molecular determinants for recognition of triazole and tetrazole analogs of histamine at H2-receptors. Mol Pharmacol 31(4):345-50. Pub Med
Namboodiri K, Osman R, Weinstein H, Rabinowitz JR. (1987). Analysis of the molecular electrostatic potential for the prediction of N-oxidation and biological activity of substituted pyridines. Mol Toxicol 1(2-3):131-41. Pub Med
Osman R. (1986). Effect of local environment and protein on the mechanism of action of superoxide dismutase. Enzyme 36(1-2):32-43. Pub Med
Weinstein H, Mazurek AP, Osman R, Topiol S. (1986). Theoretical studies on the activation mechanism of the histamine H2- receptor: the proton transfer between histamine and a receptor model. Mol Pharmacol 29(1):28-33. Pub Med
Cory RN, Osman R, Maayani S. (1986). Kinetic definition of agonist efficacy at a 5-hydroxytryptamine (5-HT2) receptor in the isolated rabbit aorta. J Pharmacol Exp Ther 236(1):48-54. Pub Med
Weinstein H, Rabinowitz J, Liebman MN, Osman R. (1985). Determinants of molecular reactivity as criteria for predicting toxicity: problems and approaches. Environ Health Perspect 61:147-62. Pub Med
Osman R, Weinstein H, Topiol S, Rubenstein L. (1985). A molecular theory of recognition and activation at a 5-HT receptor based on a quantum chemical approach to structure activity relationships. Clin Physiol Biochem 3(2-3):80-8. Pub Med
Topiol S, Weinstein H, Osman R. (1984a). A theoretical investigation of histamine tautomerism. J Med Chem 27(11):1531-4. Pub Med
Cory RN, Osman R, Maayani S. (1984). Kinetic characterization of the rabbit aorta contractile response to an alpha adrenergic agonist. J Pharmacol Exp Ther 230(1):162-70. Pub Med
Topiol S, Osman R, Schulman JM. (1984b). The two-modes-of-binding model for partial agonism and the design of partial agonists. Eur J Pharmacol 101(3-4):249- 52. Pub Med
Weinstein H, Osman R, Topiol S, Green JP. (1981). Quantum chemical studies on molecular determinants for drug action. Ann N Y Acad Sci 367:434-51. Pub Med
Osman R, Weinstein H, Topiol S. (1981). Models for active sites of metalloenzymes. II. Interactions with a model substrate. Ann N Y Acad Sci 367:356-69. Pub Med
Kang S, Ernst L, Weinstein H., Osman R. (1979). [13C]NMR chemical shifts and calculated electronic structures of serotonin congeners: relation to biological activity. Mol Pharmacol 16(3):1031-9. Pub Med
Weinstein H, Green JP, Osman R, Edwards WD. (1978). Recognition and activation mechanisms on the LSD/serotonin receptor: the molecular basis of structure activity relationships. NIDA Res Monogr 22:333-58. Pub Med
